Gut bacteria may affect whether a statin drug lowers cholesterol
Statins can be effective at lowering cholesterol, but they have a perplexing tendency to work for some people and not others. Gut bacteria may be the reason.
View ArticleDeafness shaped Beethoven's music
Progressive deafness profoundly influenced Beethoven's compositions, prompting him to choose lower-frequency notes as his condition worsened, scientists said on Tuesday.
View ArticleMitochondrial dysfunction present early in Alzheimer's, before memory loss
Mitochondria -- subunits inside cells that produce energy -- have long been thought to play a role in Alzheimer's disease. Now Mayo Clinic researchers using genetic mouse models have discovered that...
View ArticleGlobal metabolomic initiative announced: Scientists set sail on the uncharted...
Investigators at Washington University and The Scripps Research Institute have announced the launch of a "Global Metabolomic Initiative" to facilitate meta-analyses on studies of the metabolism of...
View ArticleResearchers identify novel metabolic programs driving aggressive brain tumors
Researchers at Moffitt Cancer Center have identified metabolic signatures that may pave the way for personalized therapy in glioma, a type of tumor that starts in the brain.
View ArticleMetabolomics key to identifying disease pathway: Research reveals lactic...
(Medical Xpress)—Expertise at Pacific Northwest National Laboratory contributed to the understanding of the role of cellular metabolism in the pathogenesis of a currently untreatable lung disease. This...
View ArticleNew test methods can reduce the amount of animal testing
Making more use of in-vitro testing, the upcoming 21st-century scientific fields known as 'omics' sciences and developing smart test strategies can clearly reduce the amount of essential animal...
View ArticleNew factor to control oncogene-induced senescence
An article published on the journal Nature describes the major role that Pyruvate dehydrogenase (PDH) —an enzyme of cellular energy metabolism— plays in the regulation of the cellular senescence...
View ArticleNew approach could lead to blood test to diagnose Alzheimer's in earliest stage
Blood offers promise as a way to detect Alzheimer's disease at its earliest onset, Mayo Clinic researchers say. They envision a test that would detect distinct metabolic signatures in blood plasma that...
View ArticleDirected in vitro technique may increase insulin resistance among offspring
A special type of in vitro fertilization, or IVF, may increase the risk for insulin resistance among children conceived in this way, according to a new study from Greece. The results will be presented...
View ArticleBiochemical mapping helps explain who will respond to antidepressants
Duke Medicine researchers have identified biochemical changes in people taking antidepressants – but only in those whose depression improves. These changes occur in a neurotransmitter pathway that is...
View ArticleMetabolomics: Wine and cheese, curing disease ... no doping please
Rapid developments in tools to study complex interactions are transforming biology and biomedical research.
View ArticleNew powerful tool measures metabolites in living cells
By engineering cells to express a modified RNA called "Spinach," researchers have imaged small-molecule metabolites in living cells and observed how their levels change over time. Metabolites are the...
View ArticleRevealing kidney cancer's secret: Tumors gain survival advantage by...
An international team of scientists, led by UC Davis nephrologist Robert Weiss, have used a sophisticated combination of proteomics and metabolomics to show how renal cell carcinoma (RCC) reprograms...
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